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Keywords:

  • cascade reactions;
  • natural products;
  • total synthesis;
  • vinigrol
Thumbnail image of graphical abstract

Short and sweet: A simple and practical route to the unusual tricyclic ring system found in the biologically active diterpene vinigrol is described. A remarkable proximity-induced intramolecular cycloaddition and mild Grob fragmentation allow rapid construction of the core ring system in less than 10 steps and with a minimal reliance on protecting groups.