Simultaneous Copper(I)-Catalyzed Azide–Alkyne Cycloaddition (CuAAC) and Living Radical Polymerization


  • The University of Warwick is thanked for financial support.


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All in one: CuBr/iminopyridine systems can catalyze simultaneously both copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC, “click”) and living radical polymerization (LRP) processes (see scheme). The relative rate of the two processes can be tailored by a judicious choice of the reaction conditions (solvent, temperature, [CuBr]0) leading to the development of a potentially very efficient synthetic route to well-defined functional polymers.