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Keywords:

  • antitumor agents;
  • arene ligands;
  • bioinorganic chemistry;
  • ruthenium;
  • supramolecular chemistry
Thumbnail image of graphical abstract

The start of an odyssey? The cytotoxicities of the large cationic arene–ruthenium prismatic cage 16+, and its “complex-in-a-complex” derivatives [(acac)2M⊂1]6+ (M=Pd, Pt; acac=acetylacetonate; see picture), are evaluated in comparison with free [M(acac)2]. The differences in cytotoxicity suggest that, like a “Trojan Horse”, leaching of the guest from the cage once inside a cell accelerates and increases the cytotoxic effect.