Simultaneous Determination of the Conformation and Relative Configuration of Archazolide A by Using Nuclear Overhauser Effects, J Couplings, and Residual Dipolar Couplings


  • This work was supported by the Max-Planck-Gesellschaft, the Volkswagenstiftung (Funding Initiative: “Interplay between Molecular Conformations and Biological Function”), and the Fonds der Chemischen Industrie (“Liebig-Stipendium” to D.M.). We thank Tatjana Arnold for technical support and Dr. Peter Harberz for his precious help in the preparation of the PH gel.


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Combine and conquer: Configurational assignment of remote stereogenic centers in the complex polyketide macrolide archazolide A (see structure; red O, blue N, yellow S) was accomplished by a purely NMR-based approach relying on a combination of nuclear Overhauser effects, J couplings, and residual dipolar couplings (RDCs).