Out in the cold: Amyloid fibrils formed by the protein α-synuclein, one of the key players in Parkinson's disease, are rapidly dissociated in supercooled water at −15 °C (see TEM images), conditions in which many globular proteins remain folded. NMR studies indicate that the weakening of hydrophobic and electrostatic interactions contribute to the cold-induced destabilization of the amyloid fibrils.
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