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RhI-Catalyzed Hydration of Organonitriles under Ambient Conditions

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  • This work was partially supported by a Grant-in-Aid for Young Scientists (A) and Scientific Research on the Priority Area “Advanced Molecular Transformations of Carbon Resource” from the Ministry of Education, Culture, Science, Sports and Technology of Japan, as well as by Asahi Glass and Sumitomo Foundation. We are grateful to Prof. K. Ishihara, M. Hatano, and Prof. D. Uemura (Nagoya University) for the use of GC and polarimeter instruments.

Abstract

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New scoop on scope and selectivity: The hydration of organonitriles catalyzed by a RhI(OMe) species under nearly pH-neutral and ambient conditions (25 °C, 1 atm) is chemoselective and high-yielding (93 to 99 %), has a broad substrate scope, and may thus be complementary to enzymatic hydration methods for the introduction of a terminal amido group (CONH2) onto a carbon chain.

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