M.Y. thanks the Higher Education Commission of Pakistan for support of a studentship. V.K.A. thanks the Royal Society for a Wolfson Research Merit Award and the EPSRC for a Senior Research Fellowship.
An Annulation Reaction for the Synthesis of Morpholines, Thiomorpholines, and Piperazines from β-Heteroatom Amino Compounds and Vinyl Sulfonium Salts†
Article first published online: 11 APR 2008
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 47, Issue 20, pages 3784–3786, May 5, 2008
How to Cite
Yar, M., McGarrigle, Eoghan M. and Aggarwal, Varinder K. (2008), An Annulation Reaction for the Synthesis of Morpholines, Thiomorpholines, and Piperazines from β-Heteroatom Amino Compounds and Vinyl Sulfonium Salts. Angew. Chem. Int. Ed., 47: 3784–3786. doi: 10.1002/anie.200800373
- Issue published online: 28 APR 2008
- Article first published online: 11 APR 2008
- Manuscript Received: 24 JAN 2008
- Royal Society
- vinyl sulfonium salts;
Heterocycling: Diphenyl vinyl sulfonium salt 1 acts first as an electrophile, then a base, and then again as an electrophile in this operationally simple, high yielding, one-pot synthesis of pharmacologically important morpholines, thiomorpholines, and piperazines. Compound 1 is an excellent synthon for the 1,2-ethane dication.