Communication

Temperature-Controlled Molecular Depolarization Gates in Nuclear Magnetic Resonance†

  1. Leif Schröder Dr.1,2,
  2. Lana Chavez Dr.1,2,
  3. Tyler Meldrum1,2,
  4. Monica Smith3,4,
  5. Thomas J. Lowery Dr.5,6,7,
  6. David E. Wemmer Prof.5,6,
  7. Alexander Pines Prof.1,2

Article first published online: 6 MAY 2008

DOI: 10.1002/anie.200800382

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 47, Issue 23, pages 4316–4320, May 26, 2008

Additional Information

How to Cite

Schröder, L., Chavez, L., Meldrum, T., Smith, M., Lowery, T., Wemmer, D. and Pines, A. (2008), Temperature-Controlled Molecular Depolarization Gates in Nuclear Magnetic Resonance. Angewandte Chemie International Edition, 47: 4316–4320. doi: 10.1002/anie.200800382

Author Information

  1. 1

    Lawrence Berkeley National Laboratory, Materials Sciences Division

  2. 2

    University of California Berkeley, Department of Chemistry, Berkeley CA 94720, USA, Fax: (+1) 510-486-5744

  3. 3

    Lawrence Berkeley National Laboratory, Physical Biosciences Division

  4. 4

    University of California Berkeley, Biophysics Graduate Group, Berkeley CA 94720, USA

  5. 5

    Lawrence Berkeley National Laboratory, Physical Biosciences Division

  6. 6

    University of California Berkeley, Department of Chemistry, Berkeley CA 94720, USA

  7. 7

    Current address: T2 Biosystems, Cambridge MA 02141, USA

  1. †

    Research and experiments were supported by the Director, Office of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering Division, of the US Department of Energy under Contract No. DE-AC03-76SF00098. L.S. was supported by the Deutsche Forschungsgemeinschaft (SCHR 995/1-1) through an Emmy Noether Fellowship. T.J.L. acknowledges the Graduate Research and Education in Adaptive bio-Technology (GREAT) Training Program of the UC system wide Biotechnology Research and Education Program (#2005–264).

Publication History

  1. Issue published online: 16 MAY 2008
  2. Article first published online: 6 MAY 2008
  3. Manuscript Received: 24 JAN 2008

Funded by

  • Director, Office of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering Division, of the US Department of Energy. Grant Number: DE-AC03-76SF00098
  • Deutsche Forschungsgemeinschaft. Grant Number: SCHR 995/1-1
  • UC system wide Biotechnology Research and Education Program. Grant Number: 2005–264

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Keywords:

  • biosensors;
  • imaging agents;
  • inclusion compounds;
  • thermometry;
  • xenon

Graphical Abstract

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Down the drain: Cryptophane cages in combination with selective radiofrequency spin labeling can be used as molecular “transpletor” units for transferring depletion of spin polarization from a hyperpolarized source spin ensemble to a drain ensemble. The flow of nuclei through the gate is adjustable by the ambient temperature, thereby enabling controlled consumption of hyperpolarization (see scheme).

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