J.Z. acknowledges support from the National Natural Science Foundation of China (20604011) and the National Basic Research Program of China (2007CB925103). J.Z. is a New Century Excellent Talent in University (NCET-06-0451).
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Communication
Monolayer-Barcoded Nanoparticles for On-Chip DNA Hybridization Assay†
Article first published online: 28 MAY 2008
DOI: 10.1002/anie.200800435
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Qiu, F., Jiang, D., Ding, Y., Zhu, J. and Huang, L. (2008), Monolayer-Barcoded Nanoparticles for On-Chip DNA Hybridization Assay. Angewandte Chemie International Edition, 47: 5009–5012. doi: 10.1002/anie.200800435
- †
Publication History
- Issue published online: 16 JUN 2008
- Article first published online: 28 MAY 2008
- Manuscript Received: 28 JAN 2008
Funded by
- National Natural Science Foundation of China. Grant Number: 20604011
- National Basic Research Program of China. Grant Number: 2007CB925103
- New Century Excellent Talent in University. Grant Number: NCET-06-0451
Keywords:
- barcode;
- DNA;
- mass spectrometry;
- monolayer;
- nanomaterials
Graphical Abstract
The Da Vinci Code: Monolayer-barcoded nanoparticles have been successfully prepared by simultaneous incorporation of probe elements and organic molecules. The organic species serve as mass-tagging surrogates for MS readout and allow on-chip DNA hybridization assay by laser desorption/ionization time-of-flight MS. The strategy could readily be extended to the identification of a vast range of biomolecular binding events.