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A Chiral Hypervalent Iodine(III) Reagent for Enantioselective Dearomatization of Phenols

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  • This work was partially supported by a Grant-in-Aid for Scientific Research (A) and for Encouragement of Young Scientists, and by Scientific Research on Priority Areas “Advanced Molecular Transformations of Carbon Resources” from the Ministry of Education Culture, Sports, Science, and Technology (Japan). T.D. and A.M. acknowledge support from the Industrial Technology Research Grant Program from the New Energy and Industrial Technology Development Organization (NEDO) of Japan and a research fellowship from J.S.P.S. for Young Scientists.

Abstract

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The hype about iodine(III): A chiral hypervalent iodine(III) reagent (1) is reported to enantioselectively dearomatize phenols in a highly selective manner (see scheme). This result clearly supports existence of the associative pathway in hypervalent iodine(III)-induced phenolic oxidations.

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