This work was funded in part by the DFG (Priority program “Organocatalysis” SPP1179). Generous support by the Max Planck Society, Novartis (Young Investigator Award to B.L.), the Fonds der Chemischen Industrie (Silver Award to B.L.), and AstraZeneca (Research Award in Organic Chemistry to B.L.) is gratefully acknowledged.
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Communication
Catalytic Three-Component Ugi Reaction†
Article first published online: 28 MAR 2008
DOI: 10.1002/anie.200800494
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Pan, S. C. and List, B. (2008), Catalytic Three-Component Ugi Reaction. Angewandte Chemie International Edition, 47: 3622–3625. doi: 10.1002/anie.200800494
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Publication History
- Issue published online: 21 APR 2008
- Article first published online: 28 MAR 2008
- Manuscript Received: 30 JAN 2008
Funded by
- DFG
- Max Planck Society
- Novartis
- Fonds der Chemischen Industrie
- AstraZeneca
Corrected by:
Corrigendum: Catalytic Three-Component Ugi Reaction
Vol. 47, Issue 30, 5490, Article first published online: 9 JUL 2008
Keywords:
- α-amino amides;
- phosphinic acids;
- Ugi reactions
Graphical Abstract
Perfect atom economy characterizes a novel catalytic three-component Ugi reaction (see example). Different α-amino amides are formed in good yields from aldehydes, primary amines, and isocyanides in the presence of phenyl phosphinic acid as the catalyst. The products will be useful for the synthesis of α-amino acid derivatives and in diversity-oriented synthesis.