Synthesis of (−)-Octalactin A by a Strategic Vanadium-Catalyzed Oxidative Kinetic Resolution

Authors


  • We gratefully acknowledge the University of California, Berkeley, NIHGMS (grant no. R01 GM074774), Merck Research Laboratories, Bristol-Myers Squibb, Amgen Inc., and Novartis for financial support. We thank Prof. E. Vedejs and Dr. S. T. Staben for helpful discussions.

Abstract

original image

Both products of the kinetic resolution were used in the resolution/recombination approach shown in the scheme for the enantioselective total synthesis of (−)-octalactin A. Bn=benzyl, TBS=tert-butyldimethylsilyl.

Ancillary