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Synthesis of (−)-Octalactin A by a Strategic Vanadium-Catalyzed Oxidative Kinetic Resolution


  • We gratefully acknowledge the University of California, Berkeley, NIHGMS (grant no. R01 GM074774), Merck Research Laboratories, Bristol-Myers Squibb, Amgen Inc., and Novartis for financial support. We thank Prof. E. Vedejs and Dr. S. T. Staben for helpful discussions.


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Both products of the kinetic resolution were used in the resolution/recombination approach shown in the scheme for the enantioselective total synthesis of (−)-octalactin A. Bn=benzyl, TBS=tert-butyldimethylsilyl.

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