Communication

Cyclic Peptides Bearing a Side-Chain Tail: A Tool to Model the Structure and Reactivity of Protein Zinc Sites†

  1. Olivier Sénèque Dr.1,
  2. Emilie Bourlès Dr.1,
  3. Vincent Lebrun2,
  4. Estelle Bonnet1,
  5. Pascal Dumy Prof. Dr.3,
  6. Jean-Marc Latour Dr.2

Article first published online: 24 JUL 2008

DOI: 10.1002/anie.200800677

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 47, Issue 36, pages 6888–6891, August 25, 2008

Additional Information

How to Cite

Sénèque, O., Bourlès, E., Lebrun, V., Bonnet, E., Dumy, P. and Latour, J.-M. (2008), Cyclic Peptides Bearing a Side-Chain Tail: A Tool to Model the Structure and Reactivity of Protein Zinc Sites. Angew. Chem. Int. Ed., 47: 6888–6891. doi: 10.1002/anie.200800677

Author Information

  1. 1

    Laboratoire de Chimie et Biologie des Métaux, CNRS UMR 5249, 17 rue des Martyrs, 38054 Grenoble (France), Fax: (+33) 4-3878-3462

  2. 2

    CEA, iRTSV, LCBM, 17 rue des Martyrs, 38054 Grenoble (France), Fax: (+33) 4-3878-3462

  3. 3

    Département de Chimie Moléculaire, UMR CNRS-UJF 5250, Université Joseph Fourier, Grenoble (France)

  1. †

    The authors thank Mrs. C. Lebrun for access to the ESI mass spectrometer and the Agence Nationale de la Recherche (ANR-06-JCJC-0018) for financial support.

Publication History

  1. Issue published online: 20 AUG 2008
  2. Article first published online: 24 JUL 2008
  3. Manuscript Revised: 16 JUN 2008
  4. Manuscript Received: 11 FEB 2008

Funded by

  • Agence Nationale de la Recherche. Grant Number: ANR-06-JCJC-0018

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Keywords:

  • bioinorganic chemistry;
  • cysteines;
  • NMR spectroscopy;
  • peptides;
  • zinc
Thumbnail image of graphical abstract

A near-perfect model: The design of short peptides with cyclic and linear components allows mimicking of the structure and reactivity of protein tetracysteinate zinc sites, as illustrated by the superposition of the Zn(Cys)4 site of Hsp33 (blue) and its 20 amino acid model (green).

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