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PtII-Catalyzed Synthesis of 9-Oxabicyclo[3.3.1]nona-2,6-dienes from 2-Alkynyl-1-carbonylbenzenes and Allylsilanes by an Allylation/Annulation Cascade


  • We thank the National Science Council, Taiwan for support of this work.


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Platinum is key: A new catalytic synthesis of 9-oxabicyclo[3.3.1]nona-2,6-dienes from readily available 2-alkynyl-1-carbonylbenzenes, allylsilanes, and water is reported (see scheme). This reaction sequence is proposed to proceed through a series of three reactions, including allylation of the carbonyl group, hydroalkoxylation of the alkyne, and a new ene-oxonium annulation.

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