Communication

Two-Photon Fluorescent Probes for Intracellular Free Zinc Ions in Living Tissue†

  1. Hwan Myung Kim Dr.1,
  2. Mun Sik Seo1,
  3. Myoung Jin An1,
  4. Jin Hee Hong Dr.2,
  5. Yu Shun Tian Dr.1,
  6. Joon Ho Choi2,
  7. Ohyun Kwon Dr.3,
  8. Kyoung J. Lee Prof. Dr.2,
  9. Bong Rae Cho Prof. Dr.1

Article first published online: 4 JUN 2008

DOI: 10.1002/anie.200800929

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 47, Issue 28, pages 5167–5170, June 27, 2008

Additional Information

How to Cite

Kim, H., Seo, M., An, M., Hong, J., Tian, Y., Choi, J., Kwon, O., Lee, K. and Cho, B. (2008), Two-Photon Fluorescent Probes for Intracellular Free Zinc Ions in Living Tissue. Angewandte Chemie International Edition, 47: 5167–5170. doi: 10.1002/anie.200800929

Author Information

  1. 1

    Department of Chemistry, Korea University, 1-Anamdong, Seoul 136-701 (Korea), Fax: (+82) 2-3290-3544

  2. 2

    National Creative Research Initiative Center for Neurodynamics and Department of Physics, Korea University (Korea)

  3. 3

    Samsung Advanced Institute of Technology (Korea)

  1. †

    This work was supported by a KOSEF grant funded by the Ministry of Science and Technology (MOST) (R0A-2007-000-20027-0). J.H.H., J.H.C., and K.J.L. were supported by Creative Research Initiatives of the MOST.

Publication History

  1. Issue published online: 20 JUN 2008
  2. Article first published online: 4 JUN 2008
  3. Manuscript Received: 26 FEB 2008

Funded by

  • Ministry of Science and Technology (MOST). Grant Number: R0A-2007-000-20027-0

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Keywords:

  • fluorescent probes;
  • imaging agents;
  • living tissue;
  • two-photon microscopy;
  • zinc

Graphical Abstract

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The living image: The efficient two-photon probes AZn1 and AZn2 (see picture for rat brain tissue) show 24- to 52-fold two-photon excited fluorescence enhancement in response to Zn2+. They can selectively detect intracellular free Zn2+ ions in live cells and in living tissues at a depth of 80–150 μm without interference from other metal ions and the membrane-bound probes.

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