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From Metal Complexes to Nanominerals: The Formation of Inorganic Nanoparticles on Fibrils of Transferrin
Article first published online: 21 MAY 2008
DOI: 10.1002/anie.200800930
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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How to Cite
Epple, M. (2008), From Metal Complexes to Nanominerals: The Formation of Inorganic Nanoparticles on Fibrils of Transferrin. Angewandte Chemie International Edition, 47: 4960–4961. doi: 10.1002/anie.200800930
Publication History
- Issue published online: 16 JUN 2008
- Article first published online: 21 MAY 2008
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Keywords:
- bioinorganic chemistry;
- iron;
- metalloproteins;
- mineralization;
- transferrin
Graphical Abstract
Upon drying of the iron transport protein transferrin (hTf), the originally individually coordinated Fe forms crystalline deposits of FeO(OH) (“rust”), which are periodically arranged on fibrils of the protein. This is also true for Mn and Bi minerals (the picture shows mineralization on hTF fibrils; holo/apo-hTf: hTf with/without Fe). A mineralization of this kind on fibrils could play a role in neurodegenerative diseases such as Alzheimer's.