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Keywords:

  • bioinorganic chemistry;
  • iron;
  • metalloproteins;
  • mineralization;
  • transferrin
Thumbnail image of graphical abstract

Upon drying of the iron transport protein transferrin (hTf), the originally individually coordinated Fe forms crystalline deposits of FeO(OH) (“rust”), which are periodically arranged on fibrils of the protein. This is also true for Mn and Bi minerals (the picture shows mineralization on hTF fibrils; holo/apo-hTf: hTf with/without Fe). A mineralization of this kind on fibrils could play a role in neurodegenerative diseases such as Alzheimer's.