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Keywords:

  • enzyme mimics;
  • homogeneous catalysis;
  • hydroformylation;
  • molecular recognition;
  • reduction
Thumbnail image of graphical abstract

Head 'em up, move 'em out, aldehyde! A catalytic transformation of α,β-unsaturated carboxylic acids into aldehydes through a hydroformylation–decarboxylation process has been developed (see scheme; Do=donor ligand, FG1 and FG2=complementary functional groups). The reaction proceeds at mild conditions, tolerates many functional groups, and liberates CO2 as the only stoichiometric by-product.