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A Supramolecular Catalyst for the Decarboxylative Hydroformylation of α,β-Unsaturated Carboxylic Acids


  • This work was supported by the Fonds der Chemischen Industrie, the Deutsche Forschungsgemeinschaft (GRK 1038), and an Alfried Krupp Award for young university teachers of the Krupp foundation (to B.B.). T.S. is grateful to the state of Baden-Württemberg for a Landesgraduierten Fellowship. We thank IRIS Biotech GmbH for the gift of chemicals.


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Head 'em up, move 'em out, aldehyde! A catalytic transformation of α,β-unsaturated carboxylic acids into aldehydes through a hydroformylation–decarboxylation process has been developed (see scheme; Do=donor ligand, FG1 and FG2=complementary functional groups). The reaction proceeds at mild conditions, tolerates many functional groups, and liberates CO2 as the only stoichiometric by-product.

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