We thank The Scripps Research Institute and Brandeis University for financial support, the Camille and Henry Dreyfus Foundation for a New Faculty Award, and the A.P. Sloan Foundation for a fellowship (J.-Q.Y.).
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Communication
PdII-Catalyzed Enantioselective Activation of C(sp2)![[BOND]](http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8ff.gif)
H and C(sp3)H Bonds Using Monoprotected Amino Acids as Chiral Ligands†
Article first published online: 16 MAY 2008
DOI: 10.1002/anie.200801030
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Shi, B.-F., Maugel, N., Zhang, Y.-H. and Yu, J.-Q. (2008), PdII-Catalyzed Enantioselective Activation of C(sp2)H and C(sp3)H Bonds Using Monoprotected Amino Acids as Chiral Ligands. Angew. Chem. Int. Ed., 47: 4882–4886. doi: 10.1002/anie.200801030
- †
Publication History
- Issue published online: 9 JUN 2008
- Article first published online: 16 MAY 2008
- Manuscript Received: 4 MAR 2008
Funded by
- The Scripps Research Institute
- Brandeis University
- Camille and Henry Dreyfus Foundation
Keywords:
- amino acids;
- boronic acids;
- CC coupling;
- CH activation;
- enantioselectivity
The relay of chiral information from the α-carbon atom of the amino acid ligand is believed to be crucial for chiral induction in the PdII-catalyzed enantioselective CH activation/CC coupling reaction of diphenyl(2-pyridyl)methane with boronic acids (see scheme; BQ=benzoquinone).