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Functionalized Nanocompartments (Synthosomes) with a Reduction-Triggered Release System


  • We thank BASF AG and the State of Bremen (SfBW award FV 161) for financial support. We are grateful to Prof. Dr. Werner Nau and his co-workers for assisting in the short-time fluorescence and dichroic measurements.


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An open and shut case: The developed synthosomes are a subclass of polymersomes with a block-copolymer membrane and a modified embedded transmembrane channel protein (FhuA Δ1–160; see top view of model), which acts as a selective gate. The first reduction-triggered and sterically controlled release system for transmembrane control of the chemical fluxes has been developed by chemically labeling lysine residues in the channel of FhuA Δ1–160.