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Uncovering a Latent Ligation Site for Glycopeptide Synthesis


  • Financial support from the Japan Society for the Promotion of Science (Grant-in-Aid for Creative Scientific Research no. 17GS0420) is acknowledged.


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Serine in site: A native chemical ligation concept at the serine site is described (see picture). This method was achieved by the CNBr conversion reaction from methylcysteine, which could be obtained by selective S methylation. This new method allowed a consensus sequence that is generally incorporated in N-linked oligosaccharides to be used as a ligation site in the course of glycopeptide synthesis.

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