Both authors contributed equally to this paper.
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Communication
Total Synthesis of (±)-Axinellamines A and B†
Article first published online: 20 MAR 2008
DOI: 10.1002/anie.200801138
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
O'Malley, Daniel P., Yamaguchi, J., Young, Ian S., Seiple, Ian B. and Baran, Phil S. (2008), Total Synthesis of (±)-Axinellamines A and B. Angew. Chem. Int. Ed., 47: 3581–3583. doi: 10.1002/anie.200801138
- †
We thank Prof. R. J. Quinn for a sample of authentic 1. Financial support for this work was provided by the NIH/NIGMS (GM-073949), Bristol–Myers Squibb, Eli Lilly, Merck, the Japan Society for the Promotion of Science (JSPS) for a postdoctoral fellowship to J.Y., the Natural Sciences and Engineering Research Council of Canada (NSERC) for a postdoctoral fellowship to I.S.Y., and the U.S. Department of Defense and the Hertz Foundation for predoctoral fellowships to D.P.O.
Publication History
- Issue published online: 21 APR 2008
- Article first published online: 20 MAR 2008
- Manuscript Received: 9 MAR 2008
Funded by
- NIH/NIGMS. Grant Number: GM-073949
- Bristol–Myers Squibb
- Eli Lilly
- Merck
- Japan Society for the Promotion of Science
- Natural Sciences and Engineering Research Council of Canada
- U.S. Department of Defense
- Hertz Foundation
Keywords:
- alkaloids;
- axinellamine;
- natural products;
- oxidation;
- palau'amine;
- total synthesis
Chemoselective by design: The first total synthesis of members of the axinellamine/palau'amine/massadine class of pyrrole–imidazole alkaloids features unconventional transformations on completely unprotected polyamino and hydroxylated substrates and a new method for chemoselective oxidations in such settings.