Chiral Bis(pyridylimino)isoindoles: A Highly Modular Class of Pincer Ligands for Enantioselective Catalysis


  • This work was supported by the Deutsche Forschungsgemeinschaft (SFB 623). We also acknowledge the award of a doctoral scholarship by the Studienstiftung des Deutschen Volkes (to B.K.L.)


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Protect your back: Chiral wedges (red, see scheme) at the wingtips of bis(2-pyridylimino)isoindole (bpi) pincer ligands with an appropriate protective hedge (green), to block the metal center from backside attack, in the backbone represent a new class of efficient 3d-metal catalysts. These catalysts gave excellent enantioselectivities in the iron-catalyzed hydrosilylation of arylketones and in the cobalt-catalyzed cyclopropanation of alkenes.