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Keywords:

  • asymmetric catalysis;
  • chiral phosphoric acid;
  • dynamic kinetic resolution;
  • hydrophosphonylation;
  • organocatalysis
Thumbnail image of graphical abstract

As mimics of α-amino acids, α-amino phosphonates have great promise as antibacterial and anti-HIV agents as well as protease inhibitors. Racemic α-branched aldehydes react, in the presence the new chiral phosphoric acid catalyst 1, directly with p-anisidine (PMPNH2) and a phosphite to furnish β-branched α-amino phosphonates highly diastereoselectively and enantioselectively. Anth=anthracenyl.