Controlled Cell Adhesion on PEG-Based Switchable Surfaces


  • This research was supported by the Fraunhofer Society and the Max-Planck Society (interdisciplinary network of excellence “synthetic bioactive surfaces”).


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A wash and brush up: Thermoresponsive and biocompatible oligo(ethylene glycol)-based copolymers enable the control of cell adhesion on planar gold substrates. While at physiological temperature, the polymer brushes are collapsed and enable fibroblast adhesion and cultivation, at room temperature, the now hydrated oligo(ethylene glycol) segments become cell-repellent, thus allowing cell harvesting under mild conditions (see scheme).