Modular Chemoenzymatic One-Pot Syntheses in Aqueous Media: Combination of a Palladium-Catalyzed Cross-Coupling with an Asymmetric Biotransformation


  • We thank Sonja Borchert for excellent technical support, and Evonik-Degussa, Amano Enzymes, and Oriental Yeast Company, Japan for generous support with chemicals.


original image

Two breeds of cat: A palladium-catalyzed Suzuki cross-coupling and an enzymatic reduction with an alcohol dehydrogenase from Rhodococcus sp. together enable the efficient and highly enantioselective synthesis of chiral biaryl alcohols in a one-pot process (see scheme).