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Keywords:

  • chemoenzymatic reactions;
  • chiral diols;
  • cross-coupling;
  • homogeneous catalysis;
  • one-pot synthesis
Thumbnail image of graphical abstract

Two breeds of cat: A palladium-catalyzed Suzuki cross-coupling and an enzymatic reduction with an alcohol dehydrogenase from Rhodococcus sp. together enable the efficient and highly enantioselective synthesis of chiral biaryl alcohols in a one-pot process (see scheme).