Functionalizing Glycine Derivatives by Direct C[BOND]C Bond Formation


  • This work was supported by the NSERC, CFI, and the Canada Research Chair (Tier I) program (to C.-J.L.).


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Come on glycine: Two different types of glycine derivatives are α-functionalized using cross-dehydrogenative-coupling (CDC) reactions. The method allows the efficient attachment of a malonate or aromatic alkyne group on the α-position of the glycine derivatives under very mild conditions.