A Hybrid Nanoparticle Probe for Dual-Modality Positron Emission Tomography and Magnetic Resonance Imaging


  • This work was partially supported by the KRF (MOEHRD, Basic Research Promotion Fund) (KRF-2007-331-E00166), KOSEF (R15-2004-033-06001-0), NRL (R0A-2006-000-10255), AOARD (FA4869-07-1-4016), Nano/Bio Program (M10503000218-05M0300-21810), the Korea Research Council of Fundamental Science & Technology, NCI Center for Cancer Nanotechnology Excellence, and the BK21 program of chemistry and medical college. Production of 124I was supported partially by the QURI project of MOST and KOSEF.


original image

Creating a good image: A probe for combined positron emission tomography (PET) and magnetic resonance imaging (MRI) has high colloidal stability and demonstrates facile conjugation ability. Sentinel lymph nodes are clearly identified in the fusion image (see picture; I: injection site) because of the complementary nature of the techniques, which makes accurate anatomical information and fault-free diagnosis possible.