Communication

A Hybrid Nanoparticle Probe for Dual-Modality Positron Emission Tomography and Magnetic Resonance Imaging†

  1. Jin-sil Choi2,‡,
  2. Jeong Chan Park1,‡,
  3. Hyunsoo Nah2,
  4. Seungtae Woo3,
  5. Jieun Oh1,
  6. Kyeong Min Kim Dr.5,
  7. Gi Jeong Cheon Dr.5,
  8. Yongmin Chang Prof.4,
  9. Jeongsoo Yoo Prof.1,
  10. Jinwoo Cheon Prof.2

Article first published online: 9 JUL 2008

DOI: 10.1002/anie.200801369

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 47, Issue 33, pages 6259–6262, August 4, 2008

Additional Information

How to Cite

Choi, J.-s., Park, J., Nah, H., Woo, S., Oh, J., Kim, K., Cheon, G., Chang, Y., Yoo, J. and Cheon, J. (2008), A Hybrid Nanoparticle Probe for Dual-Modality Positron Emission Tomography and Magnetic Resonance Imaging. Angew. Chem. Int. Ed., 47: 6259–6262. doi: 10.1002/anie.200801369

Author Information

  1. 1

    Department of Molecular Medicine and Nuclear Medicine, CMRI, Kyungpook National University, Daegu 700-422 (Korea), Fax: (+82) 53-426-4944

  2. 2

    Department of Chemistry, Yonsei University, Seoul 120-749 (Korea), Fax: (+82) 2-364-7050

  3. 3

    Department of Biomedical Engineering, Kyungpook National University, Daegu 700-422 (Korea)

  4. 4

    Department of Molecular Medicine and Diagnostic Radiology, Kyungpook National University, Daegu 700-422 (Korea)

  5. 5

    Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul 139-706 (Korea)

  1. ‡

    These authors contributed equally to this work.

  1. †

    This work was partially supported by the KRF (MOEHRD, Basic Research Promotion Fund) (KRF-2007-331-E00166), KOSEF (R15-2004-033-06001-0), NRL (R0A-2006-000-10255), AOARD (FA4869-07-1-4016), Nano/Bio Program (M10503000218-05M0300-21810), the Korea Research Council of Fundamental Science & Technology, NCI Center for Cancer Nanotechnology Excellence, and the BK21 program of chemistry and medical college. Production of 124I was supported partially by the QURI project of MOST and KOSEF.

  2. ‡

    These authors contributed equally to this work.

Publication History

  1. Issue published online: 29 JUL 2008
  2. Article first published online: 9 JUL 2008
  3. Manuscript Revised: 14 MAY 2008
  4. Manuscript Received: 21 MAR 2008

Funded by

  • KRF (MOEHRD, Basic Research Promotion Fund). Grant Number: KRF-2007-331-E00166
  • KOSEF. Grant Number: R15-2004-033-06001-0
  • NRL. Grant Number: R0A-2006-000-10255
  • AOARD. Grant Number: FA4869-07-1-4016
  • Nano/Bio Program. Grant Number: M10503000218-05M0300-21810
  • Korea Research Council of Fundamental Science & Technology
  • NCI Center for Cancer Nanotechnology Excellence
  • BK21 program of chemistry and medical college

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Keywords:

  • imaging agents;
  • magnetic resonance imaging;
  • manganese;
  • nanoparticles;
  • positron emission tomography
Thumbnail image of graphical abstract

Creating a good image: A probe for combined positron emission tomography (PET) and magnetic resonance imaging (MRI) has high colloidal stability and demonstrates facile conjugation ability. Sentinel lymph nodes are clearly identified in the fusion image (see picture; I: injection site) because of the complementary nature of the techniques, which makes accurate anatomical information and fault-free diagnosis possible.

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