Palladium Catalyzed Synthesis of Münchnones from α-Amidoethers: A Mild Route to Pyrroles


  • We thank the National Science and Engineering Research Council (Canada) Discovery and AGENO programs for support of this research.


original image

Having the munchies: A mild palladium-catalyzed method to activate the carbon–oxygen bond of α-amidoethers has been developed and applied to carbonylation chemistry (see scheme). A münchnone intermediate is generated in situ and undergoes a 1,3-dipolar cycloaddition with alkynes to give diversely substituted pyrroles.