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This work was supported by the ACS PRF (grant no. 47137-G1), the Emory University Research Council, and the Emory University College of Arts and Sciences.
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Communication
Enantioselective C![[BOND]](http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8ff.gif)
H Amination Using Cationic Ruthenium(II)–pybox Catalysts†
Article first published online: 18 JUL 2008
DOI: 10.1002/anie.200801445
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Milczek, E., Boudet, N. and Blakey, S. (2008), Enantioselective CH Amination Using Cationic Ruthenium(II)–pybox Catalysts. Angew. Chem. Int. Ed., 47: 6825–6828. doi: 10.1002/anie.200801445
- †
Publication History
- Issue published online: 20 AUG 2008
- Article first published online: 18 JUL 2008
- Manuscript Received: 27 MAR 2008
Funded by
- ACS PRF. Grant Number: 47137-G1
- Emory University Research Council
- Emory University College of Arts and Sciences
Keywords:
- amination;
- asymmetric catalysis ;
- CH activation;
- ruthenium
The whole “pybox” and dice: Highly enantioselective amination reactions of both allylic and benzylic CH bonds are catalyzed by cationic ruthenium(II)–pybox complexes (see structure). A novel mode of stereocontrol, which is induced by the versatile pybox ligand, is proposed to account for the excellent enantioselectivity in these reactions. Boc=tert-butoxycarbonyl, pybox=pyridine bisoxazoline.