Communication

How Useful Is Ferrocene as a Scaffold for the Design of β-Sheet Foldamers?†

  1. Somenath Chowdhury2,
  2. Gabriele Schatte Dr.3,
  3. Heinz-Bernhard Kraatz Prof.1

Article first published online: 30 JUL 2008

DOI: 10.1002/anie.200801460

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 47, Issue 37, pages 7056–7059, September 1, 2008

Additional Information

How to Cite

Chowdhury, S., Schatte, G. and Kraatz, H.-B. (2008), How Useful Is Ferrocene as a Scaffold for the Design of β-Sheet Foldamers?. Angewandte Chemie International Edition, 47: 7056–7059. doi: 10.1002/anie.200801460

Author Information

  1. 1

    Department of Chemistry, The University of Western Ontario, 1151 Richmond Street, London, ON, N6A 5B7 (Canada), Fax: (+1) 519-661-3022

  2. 2

    Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, SK, S7N 5C9 (Canada)

  3. 3

    Saskatchewan Structural Science Centre, University of Saskatchewan, 110 Science Place, Saskatoon, SK, S7N 5C9 (Canada)

  1. †

    We acknowledge support from NSERC in the form of an operating grant.

Publication History

  1. Issue published online: 27 AUG 2008
  2. Article first published online: 30 JUL 2008
  3. Manuscript Received: 27 MAR 2008

Funded by

  • NSERC

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Keywords:

  • ferrocene;
  • foldamers;
  • molecular scaffolds;
  • peptides;
  • self-assembly

Graphical Abstract

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Crease crossing peptide embossing: The first tripeptide ferrocene foldamers to adopt an extended β-sheet-like structure in solution and solid state are presented. The flexibility of peptide substituents in 1,n′-ferrocene-bispeptide conjugates was thought to prevent the formation of extended β-sheet foldamers. The results suggest that ferrocene is a valuable scaffold for extended β-sheets.

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