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How Useful Is Ferrocene as a Scaffold for the Design of β-Sheet Foldamers?

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  • We acknowledge support from NSERC in the form of an operating grant.

Abstract

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Crease crossing peptide embossing: The first tripeptide ferrocene foldamers to adopt an extended β-sheet-like structure in solution and solid state are presented. The flexibility of peptide substituents in 1,n′-ferrocene-bispeptide conjugates was thought to prevent the formation of extended β-sheet foldamers. The results suggest that ferrocene is a valuable scaffold for extended β-sheets.

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