A General and Efficient Method for the Suzuki–Miyaura Coupling of 2-Pyridyl Nucleophiles


  • We thank the National Institutes of Health (GM 46059) for support of this work. We are grateful to Merck, Amgen, and Boehringer Ingelheim for additional support. The Varian NMR instruments used in this work were purchased with funding from the NSF (CHE 9808061 and DBI 9729592).


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One of the most general systems for the cross-coupling of aryl and heteroaryl bromides and chlorides with 2-pyridyl-derived nucleophiles has been developed, for which catalysts comprising [Pd2(dba)3] and either diaryl (1) or dialkyl phosphine oxide (2) supporting ligands were found to be ideal (see scheme).