Time-Resolved Dynamic Nuclear Polarization Enhanced NMR Spectroscopy

Authors


  • S.B. acknowledges support from a Texas A&M diversity fellowship, as well as from the Texas A&M Chemistry-Biology Interface (CBI) program. C.H. thanks the Camille and Henry Dreyfus Foundation for a New Faculty Award. Support from startup monies provided by Texas A&M University is gratefully acknowledged.

Abstract

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The sensitive touch: Sensitivity constraints in NMR spectroscopy typically call for long measurement times. Hyperpolarization can enhance the time resolution of NMR spectroscopy by removing the need for signal averaging. Reactions such as enzyme catalysis can be followed in real time by hyperpolarized NMR spectroscopy through reduction in the intensity of the substrate resonance as well as the appearance of product resonances (see picture).

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