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Keywords:

  • diabetes;
  • insulin;
  • islet amyloid polypeptide;
  • protein aggregation;
  • protein design
Thumbnail image of graphical abstract

Potential aggregate preventer: The designed peptide IAPP-GI inhibits the non-native aggregation of insulin without affecting its function. As the peptide also blocks aggregation of key amyloid peptides that occur in Alzheimer's disease and type II diabetes, it is a promising drug candidate.