Ruthenium-Catalyzed Oxidative Cross-Coupling of Chelating Arenes and Cycloalkanes


  • We are grateful to the Canada Research Chair (Tier I) Foundation (C.J.L.), the NSF-EPA joint program for a Sustainable Environment, and NSERC for support of our research.


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Alkane and arene join together: Various arenes were coupled directly with simple cycloalkanes. The reaction was catalyzed by ruthenium under oxidative conditions to give substituted cycloalkylarenes regioselectively (see scheme).