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Keywords:

  • antitumor agents;
  • cell-based assays;
  • inhibitors;
  • medicinal chemistry;
  • microRNA
Thumbnail image of graphical abstract

Short, but significant, microRNAs (miRNAs) are an important class of gene regulators. Small-molecule modifiers of miRNA function, such as 1 (see schematic representation), were identified in a cellular screen for miRNA-pathway inhibitors. Such compounds are expected to be useful tools for the elucidation of detailed mechanisms of miRNA action and may serve as lead structures for the development of new therapeutic agents.