Communication

Small-Molecule Inhibitors of MicroRNA miR-21 Function†

  1. Kiranmai Gumireddy Dr.1,
  2. Douglas D. Young2,
  3. Xin Xiong Dr.2,
  4. John B. Hogenesch Prof. Dr.3,
  5. Qihong Huang Prof. Dr.1,
  6. Alexander Deiters Prof. Dr.2

Article first published online: 19 AUG 2008

DOI: 10.1002/anie.200801555

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 47, Issue 39, pages 7482–7484, September 15, 2008

Additional Information

How to Cite

Gumireddy, K., Young, Douglas D., Xiong, X., Hogenesch, John B., Huang, Q. and Deiters, A. (2008), Small-Molecule Inhibitors of MicroRNA miR-21 Function. Angew. Chem. Int. Ed., 47: 7482–7484. doi: 10.1002/anie.200801555

Author Information

  1. 1

    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104 (USA), Fax: (+1) 215-898-7952 http://www.wistar.org/research_facilities/huang/research.htm

  2. 2

    Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8204 (USA), Fax: (+1) 919-515-5079, http://www4.ncsu.edu/∼adeiter/

  3. 3

    University of Pennsylvania School of Medicine (USA)

  1. †

    This research was supported in part by the National Institutes of Health (NS059478-01) and Accelerate Brain Cancer Cure. D.D.Y. acknowledges a graduate research fellowship from the ACS Medicinal Chemistry Division. A.D. is a Beckman Young Investigator and a Cottrell Scholar. Q.H. acknowledges support from the Elsa Pardee Foundation, Breast Cancer Alliance, and the V Foundation.

Publication History

  1. Issue published online: 9 SEP 2008
  2. Article first published online: 19 AUG 2008
  3. Manuscript Revised: 20 JUN 2008
  4. Manuscript Received: 3 APR 2008

Funded by

  • National Institutes of Health. Grant Number: NS059478-01
  • Accelerate Brain Cancer Cure
  • ACS Medicinal Chemistry Division
  • Elsa Pardee Foundation
  • Breast Cancer Alliance
  • V Foundation

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (314K)

Keywords:

  • antitumor agents;
  • cell-based assays;
  • inhibitors;
  • medicinal chemistry;
  • microRNA
Thumbnail image of graphical abstract

Short, but significant, microRNAs (miRNAs) are an important class of gene regulators. Small-molecule modifiers of miRNA function, such as 1 (see schematic representation), were identified in a cellular screen for miRNA-pathway inhibitors. Such compounds are expected to be useful tools for the elucidation of detailed mechanisms of miRNA action and may serve as lead structures for the development of new therapeutic agents.

View Full Article with Supporting Information (HTML) Get PDF (314K)