Small-Molecule Inhibitors of MicroRNA miR-21 Function


  • This research was supported in part by the National Institutes of Health (NS059478-01) and Accelerate Brain Cancer Cure. D.D.Y. acknowledges a graduate research fellowship from the ACS Medicinal Chemistry Division. A.D. is a Beckman Young Investigator and a Cottrell Scholar. Q.H. acknowledges support from the Elsa Pardee Foundation, Breast Cancer Alliance, and the V Foundation.


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Short, but significant, microRNAs (miRNAs) are an important class of gene regulators. Small-molecule modifiers of miRNA function, such as 1 (see schematic representation), were identified in a cellular screen for miRNA-pathway inhibitors. Such compounds are expected to be useful tools for the elucidation of detailed mechanisms of miRNA action and may serve as lead structures for the development of new therapeutic agents.