Antimicrobial Surfaces through Natural Product Hybrids


  • We thank the Swiss National Science Foundation for support (project no. 200021-115918/1). This work is part of the planned dissertation of S.B. at ETH Zürich. We thank B. Malisova for the preparation of the Ti chips.


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The power of two! A natural product hybrid (see structure) composed of a siderophore and an antibiotic separated by a poly(ethylene glycol) linker enables the preparation of antimicrobial and cell-resistant surfaces by a simple dip-and-rinse procedure. The anachelin siderophore (left) binds strongly to TiO2 surfaces, and vancomycin is responsible for antibiotic activity.