We thank the Swiss National Science Foundation for support (project no. 200021-115918/1). This work is part of the planned dissertation of S.B. at ETH Zürich. We thank B. Malisova for the preparation of the Ti chips.
Antimicrobial Surfaces through Natural Product Hybrids†
Article first published online: 31 JUL 2008
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 47, Issue 37, pages 7123–7126, September 1, 2008
How to Cite
Wach, J.-Y., Bonazzi, S. and Gademann, K. (2008), Antimicrobial Surfaces through Natural Product Hybrids. Angew. Chem. Int. Ed., 47: 7123–7126. doi: 10.1002/anie.200801570
- Issue published online: 27 AUG 2008
- Article first published online: 31 JUL 2008
- Manuscript Received: 4 APR 2008
- Swiss National Science Foundation. Grant Number: 200021-115918/1
- ETH Zürich
- natural products;
The power of two! A natural product hybrid (see structure) composed of a siderophore and an antibiotic separated by a poly(ethylene glycol) linker enables the preparation of antimicrobial and cell-resistant surfaces by a simple dip-and-rinse procedure. The anachelin siderophore (left) binds strongly to TiO2 surfaces, and vancomycin is responsible for antibiotic activity.