1521-3773/asset/2002_left.gif?v=1&s=ac6b0d94a94d7ce7a210002b8096b42feffc0bcf)
1521-3773/asset/2002_right.gif?v=1&s=451042aa3415ae3ad0729984d26dee1866aca82e)
Communication
Native Chemical Ligation at Valine
Article first published online: 14 JUL 2008
DOI: 10.1002/anie.200801590
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
1521-3773/asset/cover.gif?v=1&s=412bc65bdcb3f0e34a94f27c1c13e908726694d4 "Angewandte Chemie International Edition")
Additional Information
How to Cite
Haase, C., Rohde, H. and Seitz, O. (2008), Native Chemical Ligation at Valine. Angew. Chem. Int. Ed., 47: 6807–6810. doi: 10.1002/anie.200801590
Publication History
- Issue published online: 20 AUG 2008
- Article first published online: 14 JUL 2008
- Manuscript Received: 4 APR 2008
Keywords:
- native chemical ligation;
- penicillamine;
- peptide ligation;
- valine
Peptide ligation at hydrophobic sites is possible with a ligation–desulfurization strategy in which penicillamine serves as a precursor of valine. The β,β-dimethylcysteine peptides reacted surprisingly fast in native chemical ligation reactions. Even the sterically crowded and unpolar Leu–Val bond can be formed in high yield.