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Keywords:

  • amino acids;
  • helical structures;
  • hydrogen bonds;
  • peptides;
  • structure elucidation
Thumbnail image of graphical abstract

A different twist: A mixed C12/C10 helix with alternating hydrogen-bond directionality has been observed in the crystal structure of the hybrid αγ peptide Boc-Leu-Gpn-Leu-Aib-OMe (see structure; Boc: tert-butoxycarbonyl; Leu: leucine; Gpn: 1-(aminomethyl)cyclohexaneacetic acid (gabapentin); Aib: aminoisobutyric acid). The structure may be generalized to a regular mixed helix.