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An Effective Strategy for the Design of Proteins with Enhanced Mechanical Stability^†

Alessandro Borgia,
Annette Steward,
Jane Clarke

Article first published online: 29 JUL 2008

DOI: 10.1002/anie.200801761

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Angewandte Chemie International Edition

Volume 47, Issue 36, pages 6900–6903, August 25, 2008

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Borgia, A., Steward, A. and Clarke, J. (2008), An Effective Strategy for the Design of Proteins with Enhanced Mechanical Stability. Angew. Chem. Int. Ed., 47: 6900–6903. doi: 10.1002/anie.200801761

Author Information

MRC Centre for Protein Engineering, University of Cambridge Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW (UK) http://www-clarke.ch.cam.ac.uk

Email: Jane Clarke (jc162@cam.ac.uk)

^†
J.C. and A.S. are supported by the Wellcome Trust (Grant number GR064417MA). J.C. is a Wellcome Trust Senior Research Fellow. A.B. is supported by a fellowship from Istituto Pasteur—Fondazione Cenci Bolognetti (Rome). We thank Dr. Robert Best for helpful comments on our design.

Publication History

Issue published online: 20 AUG 2008
Article first published online: 29 JUL 2008
Manuscript Received: 15 APR 2008

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Wellcome Trust. Grant Number: GR064417MA
Istituto Pasteur—Fondazione Cenci Bolognetti

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