Communication

Heterogeneous Enantioselective Hydrogenation of Aromatic Ketones Catalyzed by Cinchona- and Phosphine-Modified Iridium Catalysts†

  1. He-yan Jiang,
  2. Chao-fen Yang,
  3. Chun Li,
  4. Hai-yan Fu,
  5. Hua Chen Prof.,
  6. Rui-xiang Li Prof.,
  7. Xian-jun Li Prof.

Article first published online: 8 AUG 2008

DOI: 10.1002/anie.200801809

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 47, Issue 48, pages 9240–9244, November 17, 2008

Additional Information

How to Cite

Jiang, H.-y., Yang, C.-f., Li, C., Fu, H.-y., Chen, H., Li, R.-x. and Li, X.-j. (2008), Heterogeneous Enantioselective Hydrogenation of Aromatic Ketones Catalyzed by Cinchona- and Phosphine-Modified Iridium Catalysts. Angew. Chem. Int. Ed., 47: 9240–9244. doi: 10.1002/anie.200801809

Author Information

  1. Key Lab of Green Chemistry and Technology, Ministry of Education, The Institute of Homogeneous Catalysis, College of Chemistry, Sichuan University, No. 29 Wang jiang Road, Chengdu 610064 (PR China), Fax: (+86) 28-8541-2904 http://chem.scu.edu.cn/professor/chenhua.htm

  1. †

    This work was financially supported by the National Natural Science Foundation of China (No. 20272037) and the Doctor's Foundation of Education Ministry of China (No. 20030610022). The authors thank Prof. Xian-Deng Hou for his kind help during the preparation of the manuscript.

Publication History

  1. Issue published online: 12 NOV 2008
  2. Article first published online: 8 AUG 2008
  3. Manuscript Revised: 7 JUL 2008
  4. Manuscript Received: 17 APR 2008

Funded by

  • National Natural Science Foundation of China. Grant Number: 20272037
  • Doctor's Foundation of Education Ministry of China. Grant Number: 20030610022

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (350K)

Keywords:

  • alkaloids;
  • asymmetric catalysis;
  • iridium;
  • ketones;
  • supported catalysts
Thumbnail image of graphical abstract

Catalyst support: The first highly enantioselective heterogeneous hydrogenation of aromatic ketones catalyzed by Ir/SiO2 stabilized with Ph3P and modified by a chiral diamine derived from a cinchona alkaloid is described (see scheme). The reaction can be employed for the reduction of a broad range of aromatic ketones to the corresponding alcohols with high enantioselectivity.

View Full Article with Supporting Information (HTML) Get PDF (350K)