Communication

Micellar Hybrid Nanoparticles for Simultaneous Magnetofluorescent Imaging and Drug Delivery†

  1. Ji-Ho Park1,
  2. Geoffrey von Maltzahn2,
  3. Erkki Ruoslahti Prof.3,
  4. Sangeeta N. Bhatia Prof.2,
  5. Michael J. Sailor Prof.1

Article first published online: 11 AUG 2008

DOI: 10.1002/anie.200801810

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 47, Issue 38, pages 7284–7288, September 8, 2008

Additional Information

How to Cite

Park, J.-H., von Maltzahn, G., Ruoslahti, E., Bhatia, Sangeeta N. and Sailor, Michael J. (2008), Micellar Hybrid Nanoparticles for Simultaneous Magnetofluorescent Imaging and Drug Delivery. Angew. Chem. Int. Ed., 47: 7284–7288. doi: 10.1002/anie.200801810

Author Information

  1. 1

    Materials Science and Engineering Program, Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman, La Jolla, CA 92093 (USA)

  2. 2

    Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA)

  3. 3

    Burnham Institute for Medical Research at UCSB, University of California, Santa Barbara, 1105 Life Sciences Technology Bldg, Santa Barbara, CA 93106 (USA)

  1. †

    This project was funded in part with federal funds from the National Cancer Institute of the National Institutes of Health (Contract No. R01A124427-02 and U01 HL 080718). M.J.S., E.R., and S.N.B. are members of the Moores UCSD Cancer Center and the UCSD NanoTUMOR Center, under the auspices of which this research was conducted and partially supported through an NIH Grant (U54 CA 119335). J.P. thanks the Korea Science and Engineering Foundation (KOSEF) for a Graduate Study Abroad Scholarship. We thank Dr. Edward Monosov for assistance with TEM analysis.

Publication History

  1. Issue published online: 3 SEP 2008
  2. Article first published online: 11 AUG 2008
  3. Manuscript Revised: 1 JUL 2008
  4. Manuscript Received: 17 APR 2008

Funded by

  • National Cancer Institute of the National Institutes of Health. Grant Numbers: R01A124427-02, U01 HL 080718
  • NIH. Grant Number: U54 CA 119335

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Keywords:

  • antitumor agents;
  • drug delivery;
  • magnetic nanoparticles;
  • micelles;
  • quantum dots
Thumbnail image of graphical abstract

Multimodal nanoassemblies that contain magnetic nanoparticles, quantum dots, and the anticancer drug doxorubicin within a single PEG–phospholipid micelle were prepared (see scheme; PEG=poly(ethylene glycol)). When equipped with the targeting peptide F3, these nanostructures enable simultaneous targeted drug delivery and dual-mode imaging of tumor tissues by near-infrared fluorescence and NMR spectroscopy.

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