Micellar Hybrid Nanoparticles for Simultaneous Magnetofluorescent Imaging and Drug Delivery

Authors

  • Ji-Ho Park,

    1. Materials Science and Engineering Program, Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman, La Jolla, CA 92093 (USA)
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  • Geoffrey von Maltzahn,

    1. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA)
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  • Erkki Ruoslahti Prof.,

    1. Burnham Institute for Medical Research at UCSB, University of California, Santa Barbara, 1105 Life Sciences Technology Bldg, Santa Barbara, CA 93106 (USA)
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  • Sangeeta N. Bhatia Prof.,

    1. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA)
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  • Michael J. Sailor Prof.

    1. Materials Science and Engineering Program, Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman, La Jolla, CA 92093 (USA)
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  • This project was funded in part with federal funds from the National Cancer Institute of the National Institutes of Health (Contract No. R01A124427-02 and U01 HL 080718). M.J.S., E.R., and S.N.B. are members of the Moores UCSD Cancer Center and the UCSD NanoTUMOR Center, under the auspices of which this research was conducted and partially supported through an NIH Grant (U54 CA 119335). J.P. thanks the Korea Science and Engineering Foundation (KOSEF) for a Graduate Study Abroad Scholarship. We thank Dr. Edward Monosov for assistance with TEM analysis.

Abstract

original image

Multimodal nanoassemblies that contain magnetic nanoparticles, quantum dots, and the anticancer drug doxorubicin within a single PEG–phospholipid micelle were prepared (see scheme; PEG=poly(ethylene glycol)). When equipped with the targeting peptide F3, these nanostructures enable simultaneous targeted drug delivery and dual-mode imaging of tumor tissues by near-infrared fluorescence and NMR spectroscopy.

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