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Keywords:

  • chemical biology;
  • enantiomers;
  • membrane proteins;
  • natural products;
  • photoaffinity labeling
Thumbnail image of graphical abstract

Pairs of probes with recognition elements of opposite configuration can be used to detect target proteins of biologically active natural products. The diastereomeric probes shown were designed on the basis of structure–activity relationships determined for an endogenous factor that controls leaf opening and closing in the title plant. They revealed that a 38 kDa membrane protein is key to the stereospecific recognition of the natural product.