This research was supported by a Grant-in-Aid for Scientific Research on Priority Area 16073216 from MEXT and JSPS research fellowships for Y.N. We also thank the Experimental Station for Medicinal Plant Studies, Graduate School of Pharmaceutical Sciences, Tohoku University, for cultivation of the plants.
Enantiodifferential Approach for the Detection of the Target Membrane Protein of the Jasmonate Glycoside that Controls the Leaf Movement of Albizzia saman†
Article first published online: 6 AUG 2008
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 47, Issue 38, pages 7289–7292, September 8, 2008
How to Cite
Nakamura, Y., Miyatake, R. and Ueda, M. (2008), Enantiodifferential Approach for the Detection of the Target Membrane Protein of the Jasmonate Glycoside that Controls the Leaf Movement of Albizzia saman. Angew. Chem. Int. Ed., 47: 7289–7292. doi: 10.1002/anie.200801820
- Issue published online: 3 SEP 2008
- Article first published online: 6 AUG 2008
- Manuscript Received: 18 APR 2008
- chemical biology;
- membrane proteins;
- natural products;
- photoaffinity labeling
Pairs of probes with recognition elements of opposite configuration can be used to detect target proteins of biologically active natural products. The diastereomeric probes shown were designed on the basis of structure–activity relationships determined for an endogenous factor that controls leaf opening and closing in the title plant. They revealed that a 38 kDa membrane protein is key to the stereospecific recognition of the natural product.