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Keywords:

  • Conia-ene reaction;
  • cyclization;
  • heterocycles;
  • indium;
  • synthetic methods
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Conica can: The In(OTf)3-catalyzed cyclization of nitrogen- and oxygen-tethered acetylenic malonic esters gives five- to seven-membered heterocycles in moderate to excellent yields (see scheme; Tf=trifluoromethanesulfonyl). The asymmetric synthesis of (−)-salinosporamide A illustrates the synthetic utility of the method.