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We thank the Fonds der Chemischen Industrie, the Deutsche Forschungsgemeinschaft (DFG), and SFB 749 for financial support. P.A. and M.H. thank the Alexander von Humboldt Foundation for a fellowship. We also thank Chemetall GmbH (Frankfurt), Evonik Industries AG (Hanau), and BASF AG (Ludwigshafen) for generous donations of chemicals.
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Communication
Convenient Preparation of Polyfunctional Aryl Magnesium Reagents by a Direct Magnesium Insertion in the Presence of LiCl†
Article first published online: 28 JUL 2008
DOI: 10.1002/anie.200801968
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Piller, Fabian M., Appukkuttan, P., Gavryushin, A., Helm, M. and Knochel, P. (2008), Convenient Preparation of Polyfunctional Aryl Magnesium Reagents by a Direct Magnesium Insertion in the Presence of LiCl. Angew. Chem. Int. Ed., 47: 6802–6806. doi: 10.1002/anie.200801968
- †
Publication History
- Issue published online: 20 AUG 2008
- Article first published online: 28 JUL 2008
- Manuscript Received: 26 APR 2008
Funded by
- Fonds der Chemischen Industrie
- Deutsche Forschungsgemeinschaft
- SFB 749
- Alexander von Humboldt Foundation
Keywords:
- C
![[BOND]](http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8ff.gif)
C coupling; - copper catalysis;
- Grignard reaction;
- heterocycles;
- insertion reactions
In the footsteps of Victor Grignard: The simple LiCl-mediated insertion of magnesium into aryl chlorides and bromides at moderate temperatures leads to functionalized organomagnesium reagents (see scheme). An unprecedented range of functional groups may be present in the substrates (e.g. CN, CO2R, OTs, OBoc; Ts=p-toluenesulfonyl, Boc=tert-butylcarbonyloxy).