We thank Yaacov Delarea for help with electron microscopy experiments, Dr. Orit Sagi-Assif for help with FACS, and members of the Gazit research group for helpful discussions.
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Communication
Cognitive-Performance Recovery of Alzheimer's Disease Model Mice by Modulation of Early Soluble Amyloidal Assemblies†
Article first published online: 26 NOV 2008
DOI: 10.1002/anie.200802123
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Frydman-Marom, A., Rechter, M., Shefler, I., Bram, Y., Shalev, Deborah E. and Gazit, E. (2009), Cognitive-Performance Recovery of Alzheimer's Disease Model Mice by Modulation of Early Soluble Amyloidal Assemblies. Angew. Chem. Int. Ed., 48: 1981–1986. doi: 10.1002/anie.200802123
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Publication History
- Issue published online: 23 FEB 2009
- Article first published online: 26 NOV 2008
- Manuscript Revised: 2 SEP 2008
- Manuscript Received: 6 MAY 2008
Keywords:
- amyloid assemblies;
- inhibitors;
- oligomers;
- peptides;
- self-assembly
Abstract
A rationally designed oligomerization inhibitor interacts with early intermediate assemblies of amyloid-β polypeptide (Aβ) through the aromatic elements and inhibits their assembly into the toxic oligomers that cause Alzheimer's disease by a unique Cα-methylation β-breakage strategy. The electrostatic potential of the low-energy conformation of the dipeptide inhibitor bound to Aβ is shown.